DCUN1D3 Antibody

Catalog Number:

47031

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q8IWE4
NCBI Gene ID:123879
Gene Accssion:NP_775746

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human DCUN1D3

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total DCUN1D3 protein.

Applications:

WB

Background:

Covalent attachment of NEDD8 to cullins, a process called neddylation, results in nuclear cullin accumulation, which promotes cell growth, migration, and transformation. DCUN1D3 inhibits neddylation of cullins by sequestering them to the plasma membrane, thereby promoting cell differentiation. Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).

References:

appl_detail:

Western blotting:1:200-1000

Datasheet PDF