Product Datasheet  
DCUN1D3 Antibody  
Catalog Number: 47031  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q8IWE4
    NCBI Gene ID:123879
    Gene Accssion:NP_775746
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20C
  • Immunogen：  
  • Synthetic peptide of human DCUN1D3
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting:1:200-1000
  • other_names：  
  • 44M2.4; SCCRO3
  • Purification：  
  • Antigen affinity purification
  • Specificity：  
  • The antibody detects endogenous levels of total DCUN1D3 protein.
  • Applications：  
  • WB
  • Background：  
  • Covalent attachment of NEDD8 to cullins, a process called neddylation, results in nuclear cullin accumulation, which promotes cell growth, migration, and transformation. DCUN1D3 inhibits neddylation of cullins by sequestering them to the plasma membrane, thereby promoting cell differentiation. Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).



 
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