MEIOB Antibody

Catalog Number:

46611

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q8N635
NCBI Gene ID:254528
NCBI Protein:BC029829

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the C terminal of human MEIOB

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total MEIOB protein.

Applications:

IHC

Background:

Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity).

References:

appl_detail:

Immunohistochemistry: 1: 25-100

Datasheet PDF