C12orf40 Antibody

Catalog Number:

46361

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q86WS4
NCBI Gene ID:283461
NCBI Protein:BC048120

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the C terminal of human C12orf40

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total C12orf40 protein.

Applications:

IHC

Background:

Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy. The C12orf40 gene product has been provisionally designated C12orf40 pending further characterization.

References:

appl_detail:

Immunohistochemistry: 1: 40-200

Datasheet PDF