Product Datasheet  
C12orf40 Antibody  
Catalog Number: 46361  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q86WS4
    NCBI Gene ID:283461
    NCBI Protein:BC048120
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic protein corresponding to residues near the C terminal of human C12orf40
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1: 40-200
  • other_names：  
  • HEL-206; HEL-S-94
  • Purification：  
  • Antigen affinity purification
  • Specificity：  
  • The antibody detects endogenous levels of total C12orf40 protein.
  • Applications：  
  • IHC
  • Background：  
  • Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy. The C12orf40 gene product has been provisionally designated C12orf40 pending further characterization.



 
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