ZNF354A Antibody

Catalog Number:

43580

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O60765
NCBI Gene ID: 6940

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human ZNF354A

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total ZNF354A protein.

Applications:

IHC

Background:

ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Kr¨¹ppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.

References:

appl_detail:

Immunohistochemistry: 1: 30-150

Datasheet PDF