Product Datasheet  
ZNF354A Antibody  
Catalog Number: 43580  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: O60765
    NCBI Gene ID: 6940
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Fusion protein of human ZNF354A
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1: 30-150
  • other_names：  
  • EZNF; HKL1; KID1; KID-1; TCF17; HEL104
  • Purification：  
  • Antigen affinity purification
  • Specificity：  
  • The antibody detects endogenous levels of total ZNF354A protein.
  • Applications：  
  • IHC
  • Background：  
  • ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Kr¨¹ppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.



 
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