KBTBD8 antibody

Catalog Number:

43486

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q86T82
NCBI Protein#: BC117487

Form of Antibody:

pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Storage/Stability:

Immunogen:

Fusion protein of human KBTBD8

Purification:

Antigen affinity purification

Specificity/Sensitivity:

Applications:

WB, IHC

Background:

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.

References:

appl_detail:

WB dilution:1:1000-1:5000
IHC dilution:1:50-1:300

Datasheet PDF