PIAS3 Polyclonal Antibody

Catalog Number:

42699

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9Y6X2

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human E3 SUMO-protein ligase PIAS3 protein (399-628aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total PIAS3 polyclonal antibody.

Applications:

IHC

Background:

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

References:

[1]"SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."Cong L., Pakala S.B., Ohshiro K., Li D.Q., Kumar R.J. Biol. Chem. 286:43793-43808(2011). [2]"Repression

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF