Product Datasheet  
PIAS3 Polyclonal Antibody  
Catalog Number: 42699  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q9Y6X2
  • Form of Antibody：  
  • PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant human E3 SUMO-protein ligase PIAS3 protein (399-628aa)
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1:20 - 1:200
  • other_names：  
  • Protein inhibitor of activated STAT protein 3, PIAS3
  • Purification：  
  • Antigen Affinity Purified
  • Specificity：  
  • The antibody detects endogenous level of total PIAS3 polyclonal antibody.
  • Applications：  
  • IHC
  • Background：  
  • Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.



 
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