TNFSF18 Polyclonal Antibody

Catalog Number:

42693

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9UNG2

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human Tumor necrosis factor ligand superfamily member 18 protein (72-199aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total TNFSF18 polyclonal antibody.

Applications:

IHC

Background:

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation.

References:

[1]"Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: implications for function."Chattopadhyay K., Ramagopal U.A., Mukhopadhaya A., Malashkevich V.N., Dilorenzo T.P., Brenowitz M., Nathenson S.G., Almo S.C.Proc. Natl. Acad.

appl_detail:

Immunohistochemistry: 1:20 - 1:200

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