Product Datasheet  
TNFSF18 Polyclonal Antibody  
Catalog Number: 42693  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q9UNG2
  • Form of Antibody：  
  • PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant human Tumor necrosis factor ligand superfamily member 18 protein (72-199aa)
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1:20 - 1:200
  • other_names：  
  • Activation-inducible TNF-related ligand, AITRL, Glucocorticoid-induced TNF-related ligand, hGITRL, TNFSF18, AITRL, GITRL, TL6, UNQ149/PRO175
  • Purification：  
  • Antigen Affinity Purified
  • Specificity：  
  • The antibody detects endogenous level of total TNFSF18 polyclonal antibody.
  • Applications：  
  • IHC
  • Background：  
  • Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation.



 
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