IL21 Polyclonal Antibody

Catalog Number:

42683

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9HBE4

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human Interleukin-21 protein(25-162aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total IL21 polyclonal antibody.

Applications:

IHC

Background:

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

References:

[1]"Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency."Salzer E., Kansu A., Sic H., Majek P., Ikinciogullari A., Dogu F.E., Prengemann N.K., Santos-Valente E., Pickl W.F., Bilic I., Ban S.A

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF