LDLRAP1 Polyclonal Antibody

Catalog Number:

42658

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q5SW96

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human Low density lipoprotein receptor adapter protein 1 protein (59-308aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total LDLRAP1 polyclonal antibody.

Applications:

WB IHC

Background:

Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.

References:

[1]"Molecular mechanisms of autosomal recessive hypercholesterolemia."Wilund K.R., Yi M., Campagna F., Arca M., Zuliani G., Fellin R., Ho Y.K., Garcia J.V., Hobbs H.H., Cohen J.C.Hum. Mol. Genet. 11:3019-3030(2002). [2]"The full-ORF clone resource of the

appl_detail:

Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF