Product Datasheet  
LDLRAP1 Polyclonal Antibody  
Catalog Number: 42658  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q5SW96
  • Form of Antibody：  
  • PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant human Low density lipoprotein receptor adapter protein 1 protein (59-308aa)
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500 - 1:2000
    Immunohistochemistry: 1:20 - 1:200
  • other_names：  
  • Autosomal recessive hypercholesterolemia protein, LDLRAP1, ARH
  • Purification：  
  • Antigen Affinity Purified
  • Specificity：  
  • The antibody detects endogenous level of total LDLRAP1 polyclonal antibody.
  • Applications：  
  • WB IHC
  • Background：  
  • Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.



 
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