CDC16 Polyclonal Antibody

Catalog Number:

42650

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q13042

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human Cell division cycle protein 16 homolog protein (371-620aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total CDC16 polyclonal antibody.

Applications:

WB IHC

Background:

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

References:

[1]"Molecular architecture and mechanism of the anaphase-promoting complex." Chang L., Zhang Z., Yang J., McLaughlin S.H., Barford D.Nature 513:388-393(2014). [2]"Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure.

appl_detail:

Western blotting: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF