Adiponectin Polyclonal Antibody

Catalog Number:

42649

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q15848

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Adiponectin protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Adiponectin polyclonal antibody.

Applications:

WB

Background:

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

References:

[1]cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1).Maeda K., Okubo K., Shimomura I., Funahashi T., Matsuzawa Y., Matsubara K.Biochem. Biophys. Res. Commun. 221:286-289(1996) [2

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF