Transcription factor SOX-2 Polyclonal Antibody

Catalog Number:

42604

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P48431

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Transcription factor SOX-2 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Transcription factor SOX-2 polyclonal antibody.

Applications:

WB

Background:

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 By similarity. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal By similarity. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation

References:

[1]The cDNA sequence and chromosomal location of the human SOX2 gene.Stevanovic M., Zuffardi O., Collignon J., Lovell-Badge R., Goodfellow P.Mamm. Genome 5:640-642(1994)[2]Sadler L.A., Badzioch M.D., Wagner M., Graves K.A., Swaroop A., Yang-Feng T.L., Z

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF