Complement factor B Polyclonal Antibody

Catalog Number:

42533

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P00751

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Complement factor B protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Complement factor B polyclonal antibody.

Applications:

WB

Background:

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

References:

[1]"Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."Maga T.K., Nishimura C.J., Weaver A.E., Frees K.L., Smith R.J.H.Hum. Mutat. 31:E1445-E1460(2010). [2]"Gain-of-function mutations in com

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF