Ras-related GTP-binding protein A Polyclonal Antibody

Catalog Number:

42394

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q7L523

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Ras-related GTP-binding protein A protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Ras-related GTP-binding protein A polyclonal antibody.

Applications:

WB IHC

Background:

Involved in the RCC1/Ran-GTPase pathway. RRAGA may play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. biquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.

References:

[1]"Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases."Schuermann A., Brauers A., Massmann S., Becker W., Joost H.-G.J. Biol. Chem. 270:28982-28988(1995) [2]

appl_detail:

Western blotting: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF