PAX4 Polyclonal Antibody

Catalog Number:

42287

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O43316

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human Paired box protein Pax-4 protein(50-200aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total PAX4 polyclonal antibody.

Applications:

WB IHC

Background:

Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.

References:

[1]PAX4 mutations in Thais with maturity onset diabetes of the young."Plengvidhya N., Kooptiwut S., Songtawee N., Doi A., Furuta H., Nishi M., Nanjo K., Tantibhedhyangkul W., Boonyasrisawat W., Yenchitsomanus P.-T., Doria A., Banchuin N.J. Clin. Endocrino

appl_detail:

Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF