ATP-sensitive inward rectifier potassium channel 1 Polyclonal Antibody

Catalog Number:

42228

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P48048

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant huaman ATP-sensitive inward rectifier potassium channel 1 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total ATP-sensitive inward rectifier potassium channel 1 polyclonal antibody.

Applications:

WB

Background:

In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.

References:

[1]Cloning and characterization of multiple forms of the human kidney ROM-K potassium channel.Shuck M.E., Bock J.H., Benjamin C.W., Tsai T.-D., Lee K.S., Slightom J.L., Bienkowski M.J.J. Biol. Chem. 269:24261-24270(1994) [2]Alternative splicing of huma

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF