ICOSLG Polyclonal Antibody

Catalog Number:

42215

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O75144

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human ICOS ligand protein (19-256aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total ICOSLG polyclonal antibody.

Applications:

IHC

Background:

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).

References:

[1]"Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS."Yoshinaga S.K., Zhang M., Pistillo J., Horan T., Khare S.D., Miner K., Sonnenberg M., Boone T., Brankow D., Dai T., Delaney J., Han H., Hui A.

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF