NAA10 Polyclonal Antibody

Catalog Number:

42070

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P41227

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human N-alpha-acetyltransferase 10 protein(161-235aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total NAA10 polyclonal antibody.

Applications:

WB IHC

Background:

Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development.

References:

[1]Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency."Rope A.F., Wang K., Evjenth R., Xing J., Johnston J.J., Swensen J.J., Johnson W.E., Moore B., Huff C.D., Bird L.M., Care

appl_detail:

Western blotting: 1:500 - 1:5000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF