Integrin-linked protein kinase Polyclonal Antibody

Catalog Number:

42192

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q13418

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Integrin-linked protein kinase protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Integrin-linked protein kinase polyclonal antibody.

Applications:

IHC

Background:

Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

References:

[1] "Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase."Hannigan G.E., Leung-Hagesteijn C., Fitz-Gibbon L., Coppolino M.G., Radeva G., Filmus J., Bell J.C., Dedhar S.Nature 379:91-96(1996

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF