DEFB121 antibody

Catalog Number:

38216

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q5J5C9
NCBI Gene ID: 245934

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Recombinant protein of human DEFB121.

Purification:

Antibodies were purified by affinity purification using immunogen.

Specificity/Sensitivity:

The antibody detects endogenous level of total DEFB121 antibody.

Applications:

IHC,IF

Background:

¡Ò-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, ¡Ò-defensins are developmentally regulated. The family of ¡Ò-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many ¡Ò-defensins also are involved in sperm maturation and capacitation. ¡Ò-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, ¡Ò-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other ¡Ò-defensins, it does not appear to be regulated by androgens.

References:

appl_detail:

IHC 1:50 - 1:100
IF 1:50 - 1:100

Datasheet PDF