Product Datasheet  
DEFB121 antibody  
Catalog Number: 38216  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q5J5C9
    NCBI Gene ID: 245934
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein of human DEFB121.
  • reactivity：  
  • Human,Mouse,Rat
  • appl_detail：  
  • IHC 1:50 - 1:100
    IF 1:50 - 1:100
  • other_names：  
  • DEFB121; ESC42RELC
  • Purification：  
  • Antibodies were purified by affinity purification using immunogen.
  • Specificity：  
  • The antibody detects endogenous level of total DEFB121 antibody.
  • Applications：  
  • IHC,IF
  • Background：  
  • ¡Ò-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, ¡Ò-defensins are developmentally regulated. The family of ¡Ò-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many ¡Ò-defensins also are involved in sperm maturation and capacitation. ¡Ò-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, ¡Ò-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other ¡Ò-defensins, it does not appear to be regulated by androgens.



 
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