UBP1 Antibody

Catalog Number:

37699

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9NZI7
NCBI Gene ID: 7342
Gene Accssion: NP_055332

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human upstream binding protein 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total UBP1 protein.

Applications:

IHC

Background:

LBP1 (Upstream-binding protein 1), also designated UBP1, LBP1A or LBP1B, is a 540 amino acid protein that belongs to the grh/CP2 family (grainyhead transcription factor family). LBP1 is a transcriptional activator that regulates the placental expression of CYP11A1 and activates the Hemoglobin globin promoter in erythroid cells. LBP1 is responsible for repressing transcription of HIV-1 by binding to and preventing TFIID from interacting with its promoter region. Null expression of LBP1 causes uterine growth retardation in mice embryos suggesting a critical role in extraembryonic angiogenesis. LBP1 localizes to the nucleus and is expressed in adrenal tissue, Hep G2, JEG-3, and HeLa cell lines. It forms two natural variants by alternative splicing. LBP1 can form homodimers as well as heterodimers with LBP-9. LBP-9 suppresses the expression of LBP1.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF