Product Datasheet  
UBP1 Antibody  
Catalog Number: 37699  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q9NZI7
    NCBI Gene ID: 7342
    Gene Accssion: NP_055332
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from internal residues of human upstream binding protein 1
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Immunohistochemistry: 1:50-1:200
  • other_names：  
  • LBP1A; LBP1B; LBP-1B; LBP-1a
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total UBP1 protein.
  • Applications：  
  • IHC
  • Background：  
  • LBP1 (Upstream-binding protein 1), also designated UBP1, LBP1A or LBP1B, is a 540 amino acid protein that belongs to the grh/CP2 family (grainyhead transcription factor family). LBP1 is a transcriptional activator that regulates the placental expression of CYP11A1 and activates the Hemoglobin globin promoter in erythroid cells. LBP1 is responsible for repressing transcription of HIV-1 by binding to and preventing TFIID from interacting with its promoter region. Null expression of LBP1 causes uterine growth retardation in mice embryos suggesting a critical role in extraembryonic angiogenesis. LBP1 localizes to the nucleus and is expressed in adrenal tissue, Hep G2, JEG-3, and HeLa cell lines. It forms two natural variants by alternative splicing. LBP1 can form homodimers as well as heterodimers with LBP-9. LBP-9 suppresses the expression of LBP1.



 
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