CD2AP Antibody

Catalog Number:

37468

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9Y5K6
NCBI Gene ID: 23607
Gene Accssion: NP_036252

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human CD2-associated protein

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CD2AP protein.

Applications:

WB IHC

Background:

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.

References:

appl_detail:

Western blotting: 1:1000-1:5000
Immunohistochemistry: 1:100-1:300

Datasheet PDF