CAV1 Antibody

Catalog Number:

37401

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q03135
NCBI Gene ID: 857
Gene Accssion: NP_001744

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human caveolin 1, caveolae protein, 22kDa

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CAV1 protein.

Applications:

WB IHC

Background:

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

References:

appl_detail:

Western blotting: 1:1000-1:5000
Immunohistochemistry: 1:50-1:200

Datasheet PDF