Product Datasheet  
CAV1 Antibody  
Catalog Number: 37401  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q03135
    NCBI Gene ID: 857
    Gene Accssion: NP_001744
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide corresponding to residues near the N terminal of human caveolin 1, caveolae protein, 22kDa
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:1000-1:5000
    Immunohistochemistry: 1:50-1:200
  • other_names：  
  • CGL3; PPH3; BSCL3; VIP21; MSTP085
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total CAV1 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.



 
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