SCN1A/2A/3A/4A/5A/8A/9A/10A/11A/12A Antibody

Catalog Number:

37231

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9UI33
NCBI Gene ID: 11280
Gene Accssion: NP_054858.2

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human sodium channel, voltage-gated, type XI, alpha subunit

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SCN1A/2A/3A/4A/5A/8A/9A/10A/11A/12A protein.

Applications:

IHC

Background:

Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF