Product Datasheet  
SCN1A/2A/3A/4A/5A/8A/9A/10A/11A/12A Antibody  
Catalog Number: 37231  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q9UI33
    NCBI Gene ID: 11280
    Gene Accssion: NP_054858.2
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from internal residues of human sodium channel, voltage-gated, type XI, alpha subunit
  • reactivity：  
  • Hu Rt
  • appl_detail：  
  • Immunohistochemistry: 1:50-1:200
  • other_names：  
  • NaN; SNS-2; NAV1.9; SCN12A
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total SCN1A/2A/3A/4A/5A/8A/9A/10A/11A/12A protein.
  • Applications：  
  • IHC
  • Background：  
  • Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.



 
© Signalway Biotechnology All Rights Reserved.