CDH1 Antibody

Catalog Number:

36994

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P12830
NCBI Gene ID: 999
Gene Accssion: NP_004351

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human cadherin 1, type 1, E-cadherin (epithelial)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CDH1 protein.

Applications:

WB IHC

Background:

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:30-1:150

Datasheet PDF