Product Datasheet  
CDH1 Antibody  
Catalog Number: 36994  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P12830
    NCBI Gene ID: 999
    Gene Accssion: NP_004351
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from internal residues of human cadherin 1, type 1, E-cadherin (epithelial)
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Western blotting: 1:500-1:2000
    Immunohistochemistry: 1:30-1:150

  • other_names：  
  • UVO; CDHE; ECAD; LCAM; Arc-1; CD324
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total CDH1 protein.
  • Applications：  
  • WB IHC
  • Background：  

  • This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.




 
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