HCN2 Antibody

Catalog Number:

36922

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9UL51
NCBI Gene ID: 610
Gene Accssion: NP_001185

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human hyperpolarization activated cyclic nucleotide-gated potassium channel 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total HCN2 protein.

Applications:

IHC

Background:

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF