KCNH2 Antibody

Catalog Number:

36920

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q12809
NCBI Gene ID: 3757
Gene Accssion: NP_000229

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human potassium voltage-gated channel, subfamily H (eag-related), member 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total KCNH2 protein.

Applications:

WB

Background:

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.

References:

appl_detail:

Western blotting: 1:500-1:2000

Datasheet PDF