Product Datasheet  
KCNH2 Antibody  
Catalog Number: 36920  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q12809
    NCBI Gene ID: 3757
    Gene Accssion: NP_000229
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthetic peptide corresponding to residues near the C terminal of human potassium voltage-gated channel, subfamily H (eag-related), member 2
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500-1:2000
  • other_names：  
  • ERG1; HERG; LQT2; SQT1; HERG1; Kv11.1
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total KCNH2 protein.
  • Applications：  
  • WB
  • Background：  
  • This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.



 
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