NEDD4L Antibody

Catalog Number:

36649

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q96PU5
NCBI Gene ID: 23327
Gene Accssion: BC032597/Q96PU5

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total NEDD4L protein.

Applications:

IHC

Background:

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension.?

References:

appl_detail:

Immunohistochemistry: 1:100-1:300

Datasheet PDF