Product Datasheet  
NEDD4L Antibody  
Catalog Number: 36649  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q96PU5
    NCBI Gene ID: 23327
    Gene Accssion: BC032597/Q96PU5
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Fusion protein corresponding to residues near the C terminal of human neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Immunohistochemistry: 1:100-1:300
  • other_names：  
  • RSP5; NEDD4-2; NEDD4.2; hNEDD4-2
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total NEDD4L protein.
  • Applications：  
  • IHC
  • Background：  
  • This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension.?



 
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