PIP5K1B Antibody

Catalog Number:

36234

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O14986
NCBI Gene ID: 8395
Gene Accssion: BC030587

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human phosphatidylinositol-4-phosphate 5-kinase, type I, beta

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PIP5K1B protein.

Applications:

IHC

Background:

Phosphatidylinositol-4-phosphate-5-kinase (PIPK) synthesizes phosphatidylinositol-4,5-bisphosphate, which regulates various processes including cell proliferation, survival, membrane trafficking, and cytoskeletal organization. The PIPK family is divided into type I, type II and type III . Each type of the PIPK family phosphorylate distinct substrates and they contain an activation loop, which determines their enzymatic specificity and subcellular targeting . The phosphatidylinositol-4-phosphate-5-kinase type I consists of three members, PIPK I ?, ¡Ò, and ?, which are characterized by phosphorylating PI4P on the 5-hydroxyl . PIPK I ? (designated PIPK I ¡Ò in mouse) is expressed in brain tissue . PIPK I ¡Ò, designated PIPK I a in mouse, is also called STM7. PIPK I ? has two variants produced by alternative splicing which are expressed in lung, brain, and kidneys.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF