PRMT7 Antibody

Catalog Number:

35889

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9NVM4
NCBI Gene ID: 54496
Gene Accssion: BC000146

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human Protein arginine methyltransferase 7

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PRMT7 protein.

Applications:

WB

Background:

Protein arginine methyltransferase 7?is a?protein?that in humans is encoded by the?PRMT7?gene.?Arginine?methylation?is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using?S-adenosylmethionine?(AdoMet) as the methyl donor. Arginine methylation is implicated in?signal transduction, RNA transport, and?RNA splicing. May be involved in etoposide-induced cytotoxicity, a chemotherapeutic agent frequently used for testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers. Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT).

References:

appl_detail:

Western blotting: 1:500-1:2000

Datasheet PDF