SPDEF Antibody

Catalog Number:

35874

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O95238
NCBI Gene ID: 25803
Gene Accssion: BC021299

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human SAM pointed domain containing ets transcription factor

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SPDEF protein.

Applications:

IHC

Background:

The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

IHC dilution: 1:50-1:100

Datasheet PDF