Product Datasheet  
SPDEF Antibody  
Catalog Number: 35874  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: O95238
    NCBI Gene ID: 25803
    Gene Accssion: BC021299
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Fusion protein corresponding to a region derived from internal residues of human SAM pointed domain containing ets transcription factor
  • reactivity：  
  • Hu Ms
  • appl_detail：  

  • IHC dilution: 1:50-1:100

  • other_names：  
  • PDEF; bA375E1.3; RP11-375E1__A.3
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total SPDEF protein.
  • Applications：  
  • IHC
  • Background：  

  • The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.




 
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