BCL2L12 Antibody

Catalog Number:

34482

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9HB09
NCBI Gene ID: 83596

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human BCL2L12.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total BCL2L12 protein.

Applications:

WB

Background:

This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants.

Scorilas A., Genomics 72:217-221(2001) [PubMed: 11401436].
Hillman R.T., Genome Biol. 5:R8.1-R8.16(2004) [PubMed: 14759258].
Olsen J.V., Cell 127:635-648(2006) [PubMed: 17081983].

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF