AKR1C2 Antibody

Catalog Number:

34400

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P52895
NCBI Gene ID: 1646

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human AKR1C2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total AKR1C2 protein.

Applications:

WB

Background:

Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.

Qin K.-N., J. Steroid Biochem. Mol. Biol. 46:673-679(1993).
Ciaccio P.J., Biochim. Biophys. Acta 1186:129-132(1994).
Qin K.-N., Gene 149:357-361(1994).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF