Acetyl-TP53-K382 pAb

Catalog Number:

29808

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P04637
NCBI Gene ID:7157

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

A synthetic acetylated peptide around K382 of human TP53 (NP_000537.3).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF