MEP1B Polyclonal Antibody

Catalog Number:

27286

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q16820
NCBI Gene ID:4225

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human MEP1B (NP_005916.2).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.

References:

appl_detail:

WB 1:500 - 1:1000

Datasheet PDF