TET2 Antibody

Catalog Number:

25436

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q6N021
Gene ID:54790

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against an 18 amino acid peptide near the amino terminus of human TET2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least two isoforms of TET2 are known to exist; this antibody will detect both isoforms.

Applications:

ELISA WB

Background:

TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14% of patients with JAK2V617F-positive myeloproliferative neoplasms , and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia. Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.

References:

appl_detail:

Datasheet PDF